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Learn How to See Instagram Viewer List

How to see Instagram viewer list can be your most sought after secret weapon on the internet. It’s true, if you use it, you will get more traffic from your site. The reason is because it will be an easy way for you to get more people to look at your page on the social networking website. If you have ever thought about doing this, then you should know that you should do this before doing anything else.

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One thing you will want to make sure of is that you find out how to see Instagram viewer list before doing anything else. This is so that you can make certain that you are only getting traffic from people who actually are looking for the product or service you are selling.

YouTube and Google’s AdWords programs are very competitive. If you think you have the power to get more people to view your page or blog, then you need to learn how to see their Instagram viewer list. This will give you a better idea of what your competitors are doing and you can use this information to try and get more visitors to your site.

When you start to take a look at who is visiting your page, you will start to see a trend in which they are coming from a particular location. For example, if you were to see that a lot of your visitors came from Chicago, then you will be more than likely to create videos that focus on Chicago. You need to learn how to see the right type of audience so that you can create videos that will attract this type of audience.

If you want to be able to market your products online and increase traffic to your page, then you will need to learn how to see Instagram viewer list. The way that you get this information is through the links that you put into the content on your site. You can also use the social media site to advertise products that you want to sell. However, the best way to do this is to learn how to see this viewer list.

You will see that you are able to see this information when you see that the number of people that are viewing your page or blog has gone down. You can use this to figure out why this is happening. If you do this, then you can get to see what is causing the audience to leave and you can get them back once again.

If you want to know how to see Instagram viewer list, then you will want to figure out who these people are. In order to do this, you will want to use a few different methods. The first thing you can do is to go to this website and see who their followers are.

The search method works by using keywords in your search bar. You will be able to look for words like ‘Instagram viewer list’instagram list’ to narrow down your results. Once you find them, you will be able to see who they are and if they are looking for the specific page or blog you are looking for.

Another method of finding this information is by using a more traditional search method. For example, if you use Google, you will be able to search for the keywords ‘Instagram viewer list’. Once you find the page or blog you are looking for, you will be able to go to the site and see who is viewing it.

If you think about it, this may not be what most people do. This is because they only use search engines to look for people that are located within a certain area. They may not realize that they have a chance to see these lists of people.

By seeing these lists, you will be able to get information on people who have not visited your page or blog, you will be able to see what people are looking for. You can then use the information to get people to come back to your site and become a customer.

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Find Useful Advice About Starting A New Online Business

Find Out Important Information About Starting a New Online Business Let’s face it – time is one of those things you never seem to have enough of. You go through the same routine Monday through Friday: the alarm goes off at 5 AM and it’s an exercise in sleepwalking to get ready for work, eat breakfast, pack a lunch and head off to the office. Spend the next 9 hours watching the clock, wondering why your boss can’t give you some work that would require some sort of brain activity. Other days, it seems like the world’s about to end and you’re so consumed with being in Crisis Mode that its three o’clock before you realized you skipped lunch. When 5 PM rolls around, it’s back in the car for a drive that makes you secretly wonder if there’s a homicidal maniac rousing within you. Arriving at home exhausted, it’s a rush to get dinner made, get the kids fed, homework completed, baths given and storied read before bed. At that point, you have just enough energy to flop yourself down in front of the TV for an hour or so before trudging off to bed. Seven hours later, the alarm goes off and the cycle starts all over again.

Read Useful Tips About Starting a New Online Business . I was flipping channels one Sunday afternoon when I landed on a PBS special featuring Kim Kiyosaki, wife of the best selling author of “Rich Dad, Poor Dad.” Kim was talking about how women need to step up and become entrepreneurs so they can become wealthy and live the lifestyle they deserved. I had tried some home business opportunities in the past but instead of being businesses I could build from home, I found them to be 2nd jobs that had me out of the house 5 to 6 nights a week attend team meetings or pitch the business to unqualified leads. Being a wife and mother to 3 kids, I just couldn’t see how overcome the time demands of my family and my full-time job, and still build a successful home business. But a seed was planted that day and I couldn’t help hoping that there was an opportunity out there that was 100% home-based and had an income potential that would exceed my existing career.

Find Out Useful Secrets About Starting a New Online Business when I noticed an ad that compelled me to click. I was taken to a page that introduced me to a revolutionary internet marketing system that was different from anything I’d ever seen before. I got started and quickly learned that, even with a turn-key system that did 85% of the work for me, I still needed to dedicate 1 to 2 hours per day to working my business and I needed to do so EVERY SINGLE DAY.

Find Important Info About Starting a New Online Business Is 1 to 2 hours a day too much of a time commitment to build a successful business? Be honest with yourself. Are those re-runs of Seinfeld worth spending the next 10 or 20 years making someone else rich? I encourage you to think about your future. Where do you want to be in 5 years? A better question might be, if you stay on the course you’re following today, where will you be in 5 years? You can take a different direction in your life, one that will lead to more money in the bank and more time with the people and things you enjoy. Take the remote, turn off the TV right now. Get online and begin your own search for an online business that can dramatically alter your future!

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Grab vital things to know in the sphere of free traffic – make sure to read the publication. The time has come when concise information is really only one click away, use this opportunity.

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Find Out About Paid Ads Free Just before It’s Launch Throughout October

Paid Ads Free is a brand spanking new solution developed by Philip Masoor and Andrew X. This product, slated for release on October 3 of this year has recently developed great awareness and also curiosity among the folks who are connected with internet promotion. This is a paid ads free review that can assist you understand better the system plus show you its functions.

Paid ads free serves as a software program process which will teach the way to get purchased site visitors or perhaps advertising deals. A paid ads free software allows you to do it totally free as you may won’t need to shell out any sort of number of money. Combined with the computer software you receive some instruments and video lessons that will assist you to use the software program productively and proficiently. With the training videos that you will get as well as paid ads free computer software, you will learn tips to get ad spaces for free without paying for anything.

By using paid ads free application, you will be able to implement your own promotion program with posting agreements with online websites. You can generate limitless number of promotions for the internet webpages for free. As you don’t need to make payments upfront, you do not risk sacrificing some cash on investing in advertisement locations. It will aid you create a profitable advertisement business on the net, if you are willing to look into this even more. For serious participants in online marketing industry, the software may truly become very beneficial and profitable tool.

Paid ads free computer software is a fully legitimate solution and therefore you can be certain concerning the genuineness of the solution. The software is priced at $49 and there’s a 60 day money back guarantee if you aren’t happy with the effectiveness of the item. The official website of the product is paidadsfree.com. the site may be under construction and is also expected to be running together with the launch of the paid ads free software this October.

Philips Mansoor and Andrew X have mentioned that paid ads free is probably gonna be their greatest launching. They’ve talked about that the system will deliver the affiliates a huge prospect in internet promotion and make certain enormous paydays. They mention that the program is a high quality system and will be an immediate winner among the end users. It’s going to offer step by step instructions in placing paid ads on websites at no cost, which means they will not have to spend hardly any money upfront. In accordance with the developers, the affiliates can bank from the paid ads free software in a massive way with commissions of up to $1200. In addition to these, there is also a probability of getting repeating commission for life.

The people in Paid Ads free can never have to spend on the advertising that they produce on the net pages. The developers declare that the Paid ads free will be the best traffic generation strategy for at the moment.

If you’re searching to find out more about paid ads free review, then make sure to have a look at our own web site.

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Expert Advice In Choosing The Best Refrigerant

The cooling system in a refrigerator is probably the most significant inventions man has built. This technology, which is now a standard fixture in modern society, has produced an excellent effect not only in the realm of food storage, but even in medicine, science, technology, and even in recreation and culture. Fridges are utilized nowadays in both small-scale applications in the house, to large-scale storage devices in commercial establishments. However, it is essential to be aware of the differences between refrigerators for domestic use and industrial refrigeration. Experts state that the choice in refrigerant for each depends on a multitude of aspects, including the size of the machine to be employed, safety precautions, and even the area to be cooled.

There are many qualities that refrigerator users should look into in choosing coolants for industrial refrigeration or even basic home use. The first among these qualities is the boiling point of the refrigerant. Usually, chemicals with a boiling point that is below the target temperature are ideal for cooling, whereas those having a higher boiling point are definitely more effective in smaller systems. The boiling point is very important as this determines how quickly the refrigerant can turn into a vapour and therefore, take up heat and create a lower temperature. Together with a low boiling point, an excellent refrigerant should also have a high latent heat of vaporisation. This quality signifies how much heat the refrigerant must absorb before turning into vapour.

An additional refrigerant quality to be considered is safety, and this involves 2 properties: toxicity and flammability. With regard to toxicity, refrigerants are categorized into Class A (no toxicity in concentrations lower than 400 parts per million) and Class B (with toxicity detected). Flammability of refrigerants, on the contrary, is divided into 3 classes: Class 1 (totally non-flammable), Class 2 (somewhat flammable) and Class 3 (extremely flammable). Ideally, a refrigerant must be non-toxic and non-flammable. Fridges for domestic use usually contain Class A and Class 1 coolants, while industrial refrigeration can make use of higher class refrigerants since commercial entities commonly utilize rigid safety precautions.

Colour and odour should also be taken into consideration when setting up refrigerators. Refrigerants are typically colourless and odourless, but users could add colour or make use of a refrigerant with a unique odor (such as ammonia) for easy detection of leaks. Finally, firms that will make use of industrial refrigeration must look into the stability of the refrigerant to be employed. An excellent coolant must be stable; which means that it should not react with any component of the cooling system, nor should it decompose under the various pressures and temperatures of the system. This sort of quality implies that the cooling system can be utilized for extended periods without regular repair or replacement of parts and machines.

The difference between refrigerators for home use and industrial refrigeration, Australia industry experts say that it should be taken into account and will rely on numerous factors like the size of the equipment to be used, safety measures and the area to be refrigerated.

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Freelance Modifying: Part-Time On the internet Work With no Main Monetary Expense

Have you been painstaking regarding your own sentence structure? Which are the technicians associated with syntax? Are you searching for part-time on the internet work with no expense? After that, you should look at being a freelance publisher on the internet. If you’re able to consider someone else’s phrases as well as fine-tune all of them simply somewhat to create the actual purpose better, after that modifying on the internet could be a excellent chance of producing a few part-time earnings.

Warm Work-from-Home Market Freelance modifying might be an ideal on the internet work-from-home market for you personally because it is developing quickly. Consider it. That could not make use of a person providers on the internet? Businesses require web site publishers. Writers as well as content material authors require publishers. E-book writers as well as internet marketers require publishers. Anybody can easily see exactly how simple it’s to show your own modifying abilities in to an internet business, and you will begin without having trading anything through responding to work articles on the internet. Once you have normal customers, you are able to think about establishing your personal web site, internet business, as well as spending money on providers associated with an internet business.

That which you Might Modify You are able to modify supplies such as bodily publications, content articles, E-books, along with other imprinted supplies prior to they are offered towards the open public. Lots of people tend to be self-publishing much more nowadays, therefore it might be which absolutely no additional individual will appear for all those errors prior to this strikes the actual publishing push. Which means these people actually need a good publisher that will place all of the caring treatment as well as sentence structure inspections to their release. Likewise, site owners may anticipate their own web site publishers to check on for those sentence structure as well as punctuational errors given that they do not intend on listening to issues using their visitors, therefore you will want to make certain your projects is actually first class.

Modifying Assist In the event that this particular seems like a person, you will need to possess a couple of great publications close to your pc. Aspects of Design through Bill Strunk as well as At the. W. Whitened is really a traditional however goody. This particular guide will help along with design, sentence structure, as well as term utilization. Additionally, you will want to maintain a great book as well as synonym replacement tool available not just with regard to punctuational errors however the correct using particular content. There are many on the internet, however it does not harm to possess a bodily guide available in order to switch via rapidly if you want quick assist.

Just how much in order to Cost You’ll find freelance modifying gigs online for example Odesk. com, Elance. com, as well as Expert. com, however you might get compensated less cash in the beginning. Get a very first couple of customers as well as you’ll be able to cost much more after you have normal encounter below your own belt. Companies will not think hard regarding employing somebody that creates high quality function in front of routine, therefore think about signing up to these types of earlier tasks. After you have much more encounter or even your personal company, you are able to certainly cost a bigger charge possibly through the task or even hr. When the function is very comprehensive, you might you should consider getting a good by the hour price.

Operating on the internet freelance modifying work does not have in order to need lots of money. You will want to begin with a good on the internet profile as well as work at creating your own customers. This can be a ideal online company for those who wish to help to make extra cash, work at home along with versatile several hours, as well as think about developing a income opportunity from assisting battling authors.

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Mobile Malware Protection Coming

With the recent attack of the Geinimi Trojan horse on Android operating systems and the rapid growth of mobile devices tapping into the Internet has now raised the issue of protecting mobile phones from hackers. Mobile malware protection has begun springing up from a number of computer protection companies and is the beginning of the guarding of smart phones that are fast becoming the apple of hackers’ eyes.

McAfee’s Threat Report of the last quarter last year gave consumers a view on how mobile malware is spreading, stating a 46% increase in 2010 to 967 threats from 704 of the year before. It is reported that Symbian is currently the riskiest platform, Android and jail broken iPhones following behind. Even though still small compared to the flourishing malware dominance on personal computers, it is estimated that mobile security would grow to the same levels, measuring investments in billions of dollars. Adobe Flash and PDF are the most common channels of malware on mobile devices, but with their frequent security updates to Windows Flash and PDFs, McAfee points its finger to non-Microsoft operating systems to be hard hit, along with users who aren’t aware of the mobile threats as much as the computer ones and fail to protect their mobile devices.

Kapersky Lab released versions of its mobile security software for Google and RIM operating systems at the Mobile World Congress, containing less features than those for Symbian and Windows Mobile. For Blackberry, only two features were designed and surprisingly came without antivirus with the reason given that it has good encryption and have almost nonexistent malware. The version involves the remote disabling of lost or stolen devices and data deletion upon receipt of a code through SMS. For the rest of the versions for other operating systems, Kapersky antivirus is supported, all except for the new Windows Phone 7 whose low-level functions they are unable to currently access, and Apple’s iOS that is off limits due to company restrictions.

AVG boasts the free version of its security applications tops 50,000 downloads a day by Android users as the OS grows more popular, employing a similar strategy on its mobile software with Antivirus Free and Antivirus Pro. The company has not been in the mobile security software business until November 2010 when it bought DroidSecurity. Now it offers, along with the usual antivirus and antispyware, a remote data-wiping capability, “device finding” using Google Maps and GPS, and password protection on applications among others.

ESET, a creator that hasn’t missed a single wild malware since it began testing in 1998, has released a public testing beta of its Mobile Security Business Edition for Windows Mobile and Symbian. It has similar features as that of Kapersky and AVG, with a little more extra like anti-spam and SIM matching, but fronts its key feature of Remote Administration support that can remotely schedule, change, or conduct processes like audits, scans, or configurations.

Plenty more mobile security software has already been released in varying prices and abilities of protection from companies that are more known like Norton and Lookout, to the newcomers like BullGuard. It is likely to see more names as the defenses are now being set up for mobile protection to weather the predictions of experts about the rapid rise of mobile malware this year. 0

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Download Death Proof Soundtrack

Death Proof – Grindhouse is a part of the exploitation genre attributable film made in 2007. Directed by Quentin Tarantino was a part of the Grindhouse double features, the counterpart Robert Rodriguez’ Planet Terror.

“Stuntman Mike “drives his” sure-fire “car in Texas through the area and kills her of its victims. In the first part of the movie he has here in Austin girl group consisting of a Jungle Julia, Shanna and Arlene (also called the Butterfly), from the visor.

After an introduction to the lives of these three girls go to a Mexican bar, run by Warren, and are waiting for their friends. The whole time while they are observed by sitting at the bar and overheard Stuntman Mike. Stuntman Mike also learns about the also seated at the bar, Pam, she was transferred and asks for a ride. Stuntman Mike offers her to take her on the way home.

Both parties treat each other in greater detail as Stuntman Mike one of her radio show Jungle Julia Butterfly on offer advertised in accepting and provides them with a lap dance calls. After this scene leaves the drunk and stoned woman company, now with Julias Deal Erin at the wheel, the bar will continue to house and drive to the father of Shanna. Stuntman Mike’s car as Pam peculiar skepticism, this assures her that the car was “dead sure” (in English -proof death) was. In fact, Pam can only take place on a seat belt Behelfsbeifahrersitz without the addition of a pane of acrylic glass is shielded from the driver because it is the car for a stunt car is at. It is delivered Stuntman Mike’s deadly maneuvers and eventually falls victim to this.

Stuntman Mike then followed the women’s group. After he had obtained their car, he turns around behind a hill, turn the lights out of his car and drives to meet them on the wrong track. Only shortly before the collision, he switched the lights back on and be reinforced car shredded the car, including passengers.

After the alleged accident is Stuntman Mike in the hospital with a broken nose and collarbone. The four women, however, have not survived the crash. The investigating Ranger Earl McGraw under his intent, but he recognizes that he can not prove this.

Then comes the second part of the film. 14 months after the events of the first part of Mike now lives in Tennessee and drives a 1969er Dodge Charger. He makes the women’s group to Abernathy, Lee, Kim and Zoe later in Lebanon. These are in the movie business, Kim and Zoe are stunt women.

Both parties meet at the beginning of the second part at a gas station. Stuntman Mike, the group later overheard in a coffee shop and discovers that Zoë in the city a for sale Dodge Challenger, built in test drive would 1970th The women go to the provider of the car and start a test drive, and Lee remains as a deposit. During the test drive, they are viewed by Stuntman Mike, while Zoë “ship mast” is playing, that is, it is at full speed on the hood and in compliance in only two of the doors belts fastened securely. Stuntman Mike starts his car to ram the girls and the road to run them off. When he gets out, however, to laugh his putative triumph to celebrate with sardonic, he is shot by Kim and flees. Then the women decide to take revenge and to take follow-on, the tide has turned. There follows a chase, the hunter becomes the hunted and in which he makes the women found to be the last. This beat him unconscious first. After fading in the finalframes of the guy and the first round of the audience once again returned to the scene and see how the Abernathy lying on the ground Stuntman Mike finally with a kick in the face killing.

Tracklist

1. The Last Race Jack Nitzsche 2:37

2. Baby It’s You Smith 3:21

3. Paranoia Prima Ennio Morricone 3:19

4. Planning & Scheming Eli Roth & Michael Bacall 1:00

5. Jeepster T. Rex 4:09

6. Stuntman Mike Rose McGowan & Kurt Russell 0:19

7. Staggolee Pacific Gas & Electric 3:50

8. The Love You Save [May Be Your Own] Joe Tex 2:55

9. Good Love, Bad Love Eddie Floyd 2:09

10. Down In Mexico The Coasters 3:22

11. Hold Tight! Dave Dee, Dozy, Beaky, Mick & Tich 2:45

12. Sally And Jack [From The Motion Picture Blow Out] Pino Donaggio 1:24

13. It’s So Easy Willy DeVille 2:10

14. Whatever-However Tracie Thoms & Zoe Bell 0:36

15. Riot In Thunder Alley Eddie Beram 2:04

16. Chick Habit April March

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Custom Social Science Papers

Social science is also called behavior science; it refers to any discipline that dwells on the study of mankind relations, and networks of relationship within the social order. Most of disciplines that deal with abstract theories unlike the natural sciences fall under this category. The social science papers titles include: anthropology papers, sociology papers, business administration papers, development studies papers, political science papers, international relation papers, law papers, media, and communication and entertainment papers. Note that in some colleges, and university social science is a synonym for Society studies. Social science papers usually stick to a particular format for the essays, research papers, term papers, theses, project proposals, and literature dissertations/ reviews. Social science topics are many; you should always choose a topic that you not only understand well, but that has captured your attention, awareness, and curiosity.

Social science papers always demand a lot of reading, and researching for information. Your institution of learning avails all the books that you need for the research in the library. Reading bulky books is not just a hard task, but you will not be able to gather all the required information from all the books and complete your social science papers on time always. We have modern equipment, online access to many libraries, fast and efficient search engines, and search tools, access to million e-books, plus a staff committed to the customers.

Our team of graduate professional and certified writers will help you have your social papers done in the least time possible. You are wondering what we have. You can view free outlines of different social science papers, buy social science papers, buy custom social science papers, research papers on social science , learn how to write social science papers, and check topics for social science papers. Your will get all the services you need to make the best grades in your social science papers always. Your custom social science papers will be assigned to a writer in your area of specialization. You will be able to keep a track of the writer and be updated on the progress of your work. Each writer has an e-mail address where you can reach them. We have a Confidential Policy, so be assured that any information about you will not be availed to anyone whatsoever.

Our services are affordable to suit your needs andfinancial capability. We provide free delivery via e-mail, and strictly adhere to your timeline. You have a premium of non-plagiarized work. When you order for a custom paper, you will select the writing style, and the language style that your instructor recommends, the number of pages, or words, and any other specifications you need on your paper. You can buy: social science essays, social science paper, social science term paper, social science research paper, social science thesis, and social science dissertation, if you have a social paper to do and you are a blank slate on it, as these will not only get you good grades, but you will use them later as guides and assist you in writing future social science papers. Get other students envy your success; work with professionals only at www.meldaresearch.com. Never have that adrenaline rise, for fear of poor results. We are here because of you. Don’t wait. Order now

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Custom Built Gaming PC

Every computer gamer out there owns or has something similar to a custom built gaming pc. The difference between a normal personal computer that most of us posses at home, and a computer that a modern gamer uses are enormous in key areas needed for playing newer games. The custom built gaming pc outperforms normal computers in areas like CPU speed, Video Graphic card capabilities, bigger sized internal memory also known as RAM and storage devices of enormous sizes. There are also gamers that goes beyond technical details and tries to customize the external looks of their computers making it look cooler with the help of lights, sci-fi themed controllers, water tubes for cooling the hardware, multiple number of monitors and so on.

The markets that provides games for clients usually, tries to sell custom built gaming pcs also along with the game. Some games being more successful then other in pulling such a scheme. One of those popular games is World of Warcraft, with a staggering playerbase that counts over ten millions and keeps on rising, adopted this technique and succeeded in pursuing their clients in buying these expensive and high tech custom built gaming pcs. Depending on its specifications, features and capabilities a custom built gaming rig can be very expensive and there is always the risk that in a few months, your computer may become outdated for games that will be released over the next period. Computer technology is progressing every year, thus games having the ability to use more resources increasing the need for games to upgrade their computers. Following Morris’s Law in computer architecture, he predicted that the integrated circuits that are used for making computers will become smaller, the number of transistors per area being doubled every 10 years thus making them cheaper and more available for everyone. At the current rate we could expect everyone to be able to have a custom built gaming pc at his home in the next few years, prices for custom parts going lower by day.

Elite or professional gamers goes beyond the normal everyday gamer Joe, and have their own custom built controlers and input/output devices, such as custom keyboards with screens that displays certain statistics from a game and with buttons enabling macro making or dual monitors making the experience from playing a game resembling closer and closer to real life experience. Usually only professional gamers are spoiled with such gadgets, being sponsored and trained by companies in exchange for advertising revenue. All of the technology for making a custom built gaming pc is available for every client around the world as long as you are willing to pay the price for it. If you don’t got the budget to spend for such a rig then consider your self lucky because with the help of Morris’s Law and the current research for cheaper materials and cheaper work force, custom built gaming personal computers will be available for a fraction of their current price in the near future.

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Chronic Disease Driving Up Costs, Medtech Driving Them Down

[Healthcare costs have two important components — the cost of treating diseases and the costs of not treating them. In the din of discussion of rising healthcare costs, frequently the mantra is heard that medical technology is responsible for the higher costs. Yet, in the case of chronic diseases, the associated, preventable complications, which can run the gamut from heart disease, stroke, wound care, infection control and numerous other complications, reducing the exorbitant costs chronic disease complications is a primary goal of medical technology development.]

Chronic diseases continue to garner much attention due to their blame in rising healthcare costs. Obesity, for one, is gaining more attention by the day, particularly since it can be associated with or directly lead to many other healthcare problems (heart disease, hypertension, end-stage renal disease, vascular disorders, stroke), all of which contribute significantly to rising healthcare costs. Treatments are diverse, with the most effective options — at least in the short term — being those involving bariatric surgery and the use of devices like lap banding and gastric stimulation. The drawbacks are, of course, that these surgical options can be highly invasive, they do not address the root causes of obesity and as effective interventions as they may be for life threatening obesity, they sometimes represent only short term solutions.

Another major contributor to chronic disease is Type 2 diabetes, particularly for its high prevalence worldwide and its correlation with growth in the incidence of obesity. If left unchecked, its associated complications are enormously costly both in human and financial terms, yet the number of options for its effective management make it a high profile target of healthcare industry attention..

By no means representing all chronic disease and certainly recognizing the overlapping involvement of obesity and diabetes, obesity and diabetes are nonetheless among the most salient examples in which chronic disease creates enormous potential for medical technology.

Considering these two chronic conditions, we provide additional data on each that bear on the size of the opportunity to make an impact on chronic disease.

Diabetes

The most common form of diabetes, Type 2, which manifests itself more frequently in adults, represents a huge and growing segment of the global population, all the more for the fact that upwards of 80% of all cases of Type 2 diabetes are undiagnosed yet insidiously lead to a myriad of health problems like hypertension, heart disease, diabetic retinopathy, diabetic nephrophathy, stroke and other circulatory disorders.

In the chart below is shown the prevalence of diabetes (all types) by region in 2003 and forecast for 2025, illustrating dramatic regional and overall growth.

Source: International Diabetes Federation; MedMarket Diligence, LLC, report #D500, “Diabetes Management, Worldwide, 2005-2015: Products, Technologies and Markets in the U.S., Europe, Japan & Rest of World.”

The presentation of type 2 diabetes has a high correlation with cardiovascular disease and obesity; overweight middle-aged people age are much likelier to develop the condition than individuals of normal weight. The associated costs of treating the condition and its complications are vast compared with the cost of the drugs that are currently available. This explains why diabetes has become a prime candidate for disease management programs; pharmacy benefit managers see a good opportunity to reduce the overall cost of the disease through better and earlier intervention with medicines.

The size of the patient population, its steady growth – especially rapid in developing world countries enjoying new prosperity – and the limitations of current treatments mean that diabetes has become a major R&D focus for many of the world’s largest drug companies. These include Bayer, Pfizer and Servier, as well as Eli Lilly, Novo Nordisk and Sanofi-Aventis, and biotechnology companies such as Amylin.

Unlike Type 1 diabetes (juvenile onset), which is characterized by lack of insulin production, Type 2 diabetes is variably characterized as being associated with either with patients’ inadequate insulin production or production of ineffective forms of insulin. This requires different therapeutic regimens to either provide insulin or other drugs that can moderate the patient’s sensitivity to insulin in order to effectively regulate blood glucose levels.

While drugs and devices for the monitoring and treatment of type 2 diabetes are well established, this does not equate with lack of opportunity in the market, given the trend in prevalence, untapped patient population, accelerating healthcare costs and other drivers. In fact, tremendous opportunities exist for better drugs (e.g., considering recent questions about Avandia), less invasive glucose measurement (e.g., painless lancing, near-infrared or similar non-invasive approaches), less invasive delivery of insulin (although Exubera, the inhalable insulin from Pfizer was approved in early 2006, questions about respiratory effects and other questions have dampened the — one might say — overly “exuberant” potential for this drug), and other treatments to improve clinical outcomes and further penetrate the undiagnosed type 2 population.

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